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resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR/HER2 advanced breast cancer (ABC).review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR/HER2 ABC.addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer.Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer., = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063,Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: partner of breast cancer 1, early-onset (BRCA1).However, the role of MID2 in breast cancer remains unknown.This study investigated the expression, prognostic value, and role of MID2 in breast cancer.The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established, archived breast cancer tissue.

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 186-195 doi: 10.1007/s11705-015-1540-4

Abstract: reported in several types of cancer.in human breast cancer cells, though these two proteins are encoded by separate genes created by a gene, revealed Tra2 proteins are essential for breast cancer cell viability, and led to the identificationBreast cancer cells depleted for Tra2 proteins have reduced CHK1 protein levels and accumulate DNA damageThese data suggest Tra2 proteins and/or their splicing targets as possible cancer drug targets.

Keywords： RNA splicing     gene expression     breast cancer     DNA damage     CHK1    

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Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 452-458 doi: 10.1007/s11684-009-0080-z

Abstract: studies that addressed whether reproductive factors and oral contraceptive use were associated with breastcancer by searching the MEDLINE, PubMed, Proquest, Embase, ScienceDirect, African Healthline, BMJ Healthcancer risk while the summary OR based on number of full-term pregnancies ≥1 (OR, 0.63*; 95% CIbreast cancer risk.cancer risk while breast-feeding and number of full-term pregnancies ≥1 are protective factors

Keywords： meta-analysis     breast cancer     risk factors     reproductive factors     oral contraceptive use    

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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer is one of the most common malignancies that seriously threaten women’s health.In the process of the malignant transformation of breast cancer, metabolic reprogramming and immune evasionBreast cancer cells generate energy through increased glucose metabolism.For tumor-associated immunity, poor immunogenicity and heightened immunosuppression cause breast cancercancer.

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 443-446 doi: 10.1007/s11684-009-0079-5

Abstract: kinase (ERK), c-Jun N-terminal Kinase (JNK), and the expression of cytochrome P450 (CYP) subtype CYP2J2However, atorvastatin did not alter the expression of CYP2J2 in tumor tissue.These effects were not dependent on down-regulation of CYP2J2 expression.

Keywords： atorvastatin     xenograft tumor     metastasis     CYP2J2    

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A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 212-216 doi: 10.1007/s11684-012-0185-7

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Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 482-489 doi: 10.1007/s11705-013-1342-5

Abstract: which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancercell lines like colon, prostate and breast.enzymatic treatment was carried out with Rohapect DA6L under the following conditions: 50°C, pH 4.0, 2%and DP6 ; 4.7% with DP2; and 28.8% with DP1.The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line

Keywords： pectic extracts     antiproliferative activity     breast cancer     enzymatic treatment    

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract:

Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increasedPrevious studies focused on cancer cells, but an increasing number of recent studies have analyzed thecontribution of cancer microenvironment to the initiation and progression of breast cancer.also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer.In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymalstudy aimed to investigate the contributions of EMT and related factors in lymph node metastasis of breastcancer.(COX-2), and CD34 were examined in 74 cases of breast cancer, including 39 cases with lymph node metastasiswith lymph node metastasis in breast cancer.

Keywords： epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9     cyclooxygenase-2     higher microvascular density     breast cancer    

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Soy food consumption in relation to breast cancer modified by menopause status

YANG Rong, ZHANG Bin, YANG Shaoping, ZHANG Dan, DU Yukai

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 348-351 doi: 10.1007/s11684-008-0066-2

Abstract: The mortality of breast cancer in Wuhan city is increasing, according to the statistics of recent yearsThis case control study was aimed to provide data for alimentary therapeutics for breast carcinomas.indicate that intake of soy foods more than 5 times per week was associated with a decreased risk of breastcancer, especially in premenopausal women.Our results indicate that alimentary therapeutics for breast cancer can be adjusted by status of menopause

Keywords： development     control     lifestyle     consumption     information    

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Title Author Date Type Operation

resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Journal Article

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Journal Article

A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Journal Article

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article

Soy food consumption in relation to breast cancer modified by menopause status

YANG Rong, ZHANG Bin, YANG Shaoping, ZHANG Dan, DU Yukai

Journal Article